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(1)







              

ྡྂᒇ኱Ꮫ኱Ꮫ㝔་Ꮫ⣔◊✲⛉㸦◊✲⛉㛗࣭㧘ᶫ㞞ⱥ㸧ศᏊ⣽⬊ච␿Ꮫࡢ㕥ᮌ

἞ᙪ㸦ࡍࡎࡁࡣࡿࡦࡇ㸧෸ᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊච␿ไᚚ࡟῝ࡃ㛵ࢃࡗ࡚࠸

Fas/FasL⤒㊰࡟ࡘ࠸࡚ࠊ࡝ࡢ⣽⬊㞟ᅋࡀ࡝ࡢࢱ࢖࣑ࣥࢢ࡛ࠊFas/FasL⤒㊰ࢆ

౑⏝ࡋ࡚⏕యෆ࡛ാ࠸࡚࠸ࡿ࠿࡟ࡘ࠸࡚᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ

ᮏ◊✲ᡂᯝࡣࠊ⡿ᅜᏛ⾡ㄅࠕProceedings of the National Academy of Science, USAࠖ ⡿ᅜ᫬㛫  ᖺ㸰᭶  ᪥ࡢ㟁Ꮚ∧㸧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ

Fas/FasL⤒㊰ࡣྂࡃ࠿ࡽ▱ࡽࢀ࡚࠸ࡿ࢔࣏ࢺ࣮ࢩࢫ⤒㊰࡛࠶ࡾࠊච␿ไᚚ࡟῝ ࡃ࠿࠿ࢃࡗ࡚࠸ࡲࡍࠋࡋ࠿ࡋࠊ⏕యෆ࡛ࡢᙺ๭࡟ࡘ࠸࡚ࡢヲ⣽ࡣࠊࡇࢀࡲ࡛᫂ࡽ

࠿࡟࡞ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ௒ᅇࠊ◊✲ࢢ࣮ࣝࣉࡣࠊ⣽⬊ቑṪࢆไᚚࡍࡿάᛶࢆ

 ᐃࡍࡿ

in vitro

⣽⬊ᇵ㣴ᐇ㦂⣔ࢆ᪂ࡓ࡟ᵓ⠏ࡋࠊࡉࡽ࡟ࡣࠊ⏕యෆ࡛ࡢᙺ๭ࢆ

ぢࡿࡇ࡜ࡀ࡛ࡁࡿ

in vivo

ࡢ࢔ࢵࢭ࢖ࢆ⾜࠸ࠊCD8

T⣽⬊ࡢ࠺ࡕ࡝ࡢ⣽⬊ศ⏬ࡀ ไᚚάᛶࢆ᭷ࡍࡿ࠿ࢆ᳨ウࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ

in vitro

ࡢᐇ㦂࡟࠾࠸࡚ CD8

CD122CD49dlowศ⏬ࡀ᭱ࡶไᚚάᛶࡀ㧗࠸ࡇ࡜ࠊࡉࡽ࡟࣐࢘ࢫ⏕యෆ㸦

in vivo

࡟ ࠾ ࠸ ࡚ ࡶ ࡇ ࡢ ศ ⏬ ࡢ ⣽ ⬊ ࡟ ࡼ ࡿ ᢚ ไ ࡀ ᭷ ຠ ࡟ ᶵ ⬟ ࡋ ࡚ ࠸ ࡿ ࡇ ࡜ ࢆ Ⓨ ぢ ࡋ ࡲ ࡋ ࡓࠋࡲࡓࠊFasศᏊࡢാ࠿࡞࠸࣐࢘ࢫ࡛࠶ࡿ

lpr

࣐࢘ࢫ࡜FasLࡢാ࠿࡞࠸࣐࢘ࢫ

࡛࠶ࡿ

gld

࣐࢘ࢫࢆ⏝࠸ࠊFas/FasL⤒㊰࡟␗ᖖࡢ࠶ࡿ⣔࡛ࡣࡇࡢᢚไ⤒㊰ࡀാ࠿

࡞࠸ࡇ࡜ࢆ

lpr

gld

࣐࢘ࢫ⏤᮶ࡢ 7 ⣽⬊ᇵ㣴ᐇ㦂⣔㸦

in vitro

㸧࡜࣐࢘ࢫ⏕యࢆ

⏝࠸ࡓᐇ㦂⣔㸦

in vivo

㸧ࡢ཮᪉࡟࠾࠸࡚ࡶド᫂ࡋࡲࡋࡓࠋ

ࡇࡢ⤖ᯝࠊࡇࢀࡲ࡛୙࡛᫂࠶ࡗࡓ Fas ཬࡧ FasL ࡀࠊ࡝ࡢ⣽⬊㛫࡛ാࡁࠊ࠸ࡘ

ാࡃࡇ࡜ࡀච␿ไᚚ࡟࡜ࡗ࡚ࠊ࡝ࡢࡼ࠺࡞ព࿡ࢆᣢࡗ࡚㔜せ࡞ࡢ࠿࡜࠸࠺ၥ࠸࡟ ᑐࡋ࡚ࠊ⟅࠼ࡀࠊάᛶ໬T⣽⬊࡜CD8

CD122CD49dlowไᚚᛶT⣽⬊࡜ࡢ㛫࡛

ാࡁࠊච␿཯ᛂࡢ཰᮰᫬࡟άᛶ໬ T ⣽⬊࡟࢔࣏ࢺ࣮ࢩࢫࢆㄏᑟࡋ࡚ࠊᩘࢆῶࡽࡍ

࡜࠸࠺ព࿡࡟࠾࠸࡚㔜せ࡛࠶ࡿ࡜ᑟࡁฟࡉࢀࡲࡍࠋࡉࡽ࡟ࠊMHC class IࢆⓎ⌧ ࡋ࡞࠸㑇ఏᏊ⤌ࡳ᥮࠼࣐࢘ࢫ࡛࠶ࡿǃ2-microglobulin ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡢᐇ㦂

࡛ࡣࠊMHC class IศᏊࢆḞᦆࡍࡿCD8T⣽⬊ࡀࠊࡇࡢᢚไస⏝ࢆཷࡅࡲࡏࢇࠋ ࡇࡢࡇ࡜࡟ࡼࡾࠊCD8

ไᚚᛶT ⣽⬊ࡀάᛶ໬T ⣽⬊ࢆㄆ㆑ࡍࡿࡓࡵ࡟ࡣࠊTCR

࡜MHC class I࡜ࡢ┦஫స⏝ࡀᚲせ࡛࠶ࡿࡇ࡜ࡀุ᫂ࡋࠊࡑࢀࢆド᫂ࡋࡲࡋࡓࠋ



CD8

CD122

CD49d

low

ไᚚᛶ T ⣽⬊ࡣ Fas/FasL ⤒㊰ࢆ௓ࡋࡓ

άᛶ໬ T ⣽⬊ࡢയᐖ࡟ࡼࡾ T ⣽⬊ࡢᜏᖖᛶࢆ⥔ᣢࡍࡿ



ᖹᡂ  ᖺ㸰᭶  ᪥

(2)

CD8CD122CD49dlowไᚚᛶT⣽⬊ࡣFas/FasL⤒㊰ࢆ௓ࡋࡓάᛶ໬T⣽⬊ࡢയᐖ࡟

ࡼࡾT⣽⬊ࡢᜏᖖᛶࢆ⥔ᣢࡍࡿ

࣏࠙࢖ࣥࢺࠚ

ż ࣓࣮ࣔࣜ⣽⬊ᵝCD8⣽⬊ࡢ୰࡛ࡣࠊCD49dlow⣽⬊ࡀCD49dhigh⣽⬊ࡼࡾࡶᙉ࠸ච␿ไᚚά ᛶࢆᣢࡘ

ż CD8ไᚚᛶT⣽⬊ࡣTCRࢆ⏝࠸࡚άᛶ໬T⣽⬊ࢆㄆ㆑ࡍࡿ

ż CD8ไᚚᛶT⣽⬊ࡣࠊάᛶ໬T⣽⬊࡟Fas/FasL⤒㊰ࢆ௓ࡋࡓ⣽⬊Ṛࢆㄏᑟࡍࡿࡇ࡜࡛ච

␿ไᚚάᛶࢆⓎ᥹ࡍࡿ

࠙⫼ᬒࠚ

ච␿࡟ࡣ㐺ᗘࡢᢚไࡀᚲせ࡛ࠊࡑࡢࡓࡵ࡟࠸ࡃࡘࡶࡢ␗࡞ࡗࡓ࣓࢝ࢽࢬ࣒࡛ᢚไ㸦ไᚚ㸧ࡀ

ാࡃࡼ࠺࡟࡞ࡗ࡚࠸ࡲࡍࠋไᚚᛶT⣽⬊࡜࠸࠺≉ู࡞T⣽⬊ࡀᏑᅾࡋࠊච␿ᛂ⟅ࢆᢚ࠼࡚࠸ࡿ ࡇ࡜ࡀࢃ࠿ࡗ࡚ࡁࡲࡋࡓࡀࠊࡑࢀࡣ୺࡟CD4

࡛࠶ࡾእ᮶ᛶᢠཎ࡟཯ᛂࡍࡿT⣽⬊㸦CD4+Treg

࡛࠶ࡾࡲࡍࠋච␿ᛂ⟅඲యࡢࣂࣛࣥࢫࢆ࡜ࡾ࡞ࡀࡽไᚚࢆ⾜࠺࡟ࡣCD4

࡜୪ࡪࡶ࠺㸯᪉ࡢ⣽

⬊㞟ᅋ࡛࠶ࡿCD8

ࡢෆᅾᛶᢠཎ࡟཯ᛂࡍࡿไᚚᛶT⣽⬊ࡀᚲせ࡜ᛮࢃࢀࡲࡍࠋ◊✲ࢢ࣮ࣝࣉ ࡣࡇࢀࡲ࡛ࠊCD122IL-2ཷᐜయE㙐㸧ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡢస〇࡜ゎᯒࢆ⾜࠸㸦Science, 268:1472-6, 1995CD122ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ࡟⌧ࢀ࡚ࡃࡿ␗ᖖάᛶ໬T⣽⬊ࡀఱࡽ࠿ࡢไ

ᚚᛶT⣽⬊ࡢḞⴠ࡟ࡼࡿࡶࡢ࡛࠶ࡿ㸦J Exp Med, 190:1561-72, 1999㸧ࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋ ࡓࠋࡑࡋ࡚ࠊࡑࢀࡣCD4+Treg௨እ࡟CD8+CD122+ࡢ୰࡟ࡶ࠶ࡿ㸦CD8+CD122+ไᚚᛶT⣽⬊ࠊ J Exp Med, 200:1123-34, 2004㸧ࡇ࡜ࢆⓎ⾲ࡋ࡚ࡁࡲࡋࡓࠋ

ࡇࡢࡼ࠺࡞ච␿ไᚚ࡟࠿࠿ࢃࡿศᏊࡢ୍ࡘ࡜ࡋ࡚FasFasLࡀ࠶ࡾࠊFas1989ᖺ࡟㒔

❧⮫ᗋ◊㸦ᙜ᫬㸧ࡢ⡿ཎఙ༤ኈࡽ࡟ࡼࡗ࡚ⓎぢࡉࢀࡓศᏊ࡛ࠊࡑࡢ㑇ఏᏊࡣ1991ᖺ࡟኱㜰኱ Ꮫ㸦ᙜ᫬㸧ࡢ㛗⏣㔜୍༤ኈࡽ࡟ࡼࡗ࡚ࢡ࣮ࣟࢽࣥࢢࡉࢀࡲࡋࡓࠋࡲࡓࠊ Fasࡢ⤖ྜࡍࡿ┦ᡭ࡛

࠶ࡿFasLࡢ㑇ఏᏊࡶ㛗⏣༤ኈࡽ࡟ࡼࡗ࡚ࢡ࣮ࣟࢽࣥࢢࡉࢀࡲࡋࡓࠋࡋ࠿ࡋ࡞ࡀࡽ⏕యෆ࡟࠾

࠸࡚ࡇࢀࡽࡢศᏊࡀࠊ⣽⬊࡛ࣞ࣋ࣝ࡝ࡢࡼ࠺࡟ാࡁච␿ไᚚࢆ⾜ࡗ࡚࠸ࡿࡢ࠿ࡢヲ⣽ࡣ୙᫂ࡢ

ࡲࡲ࡛ࡋࡓࠋ

ᮏ◊✲ᡂᯝ࡟ࡼࡗ࡚ࠊ๓㏙ࡢCD8+CD122+ไᚚᛶT⣽⬊ࢆࡉࡽ࡟CD49dࡢⓎ⌧࡟ࡼࡗ࡚⤠

ࡾ㎸ࡴࡇ࡜ࡀ࡛ࡁࡿࡇ࡜ࠊࡑࡢไᚚᶵᗎࡀFas/FasL⣔ࢆ௓ࡋࡓ⣽⬊യᐖ࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿

࡟ࡋࡲࡋࡓࠋ

࠙◊✲ᡂᯝࠚ

CD8+ไᚚᛶT⣽⬊㸦CD8+CD122+⣽⬊㸧ࢆࡉࡽ࡟ヲ⣽࡟ぢศࡅࡿ⣽⬊⾲㠃࣐࣮࣮࢝CD49d

ࢆぢฟࡋࠊ୰࡛ࡶCD49dlow⣽⬊ࡀάᛶ໬T⣽⬊࡟ᑐࡋ᭱ࡶᙉ࠸⣽⬊യᐖస⏝ࢆ♧ࡍࡇ࡜ࢆⓎ ぢࡋࡲࡋࡓࠋᅗ㸯࡛♧ࡍ඾ᆺⓗ࡞⤖ᯝ࡟ࡼࡿ࡜ࠊCD8+CD122+CD49dlow⣽⬊࡜CD8+CD122-

⬊࡜ࡢ౪ᇵ㣴࡛ࡣࠊCD8+CD122-⣽⬊ࡢ᪉ࡀ୍᪉ⓗ࡟ῶࡗ࡚ࡋࡲ࠸ࡲࡍࡀࠊ

CD8+CD122+CD49dhigh⣽⬊࡜CD8+CD122-⣽⬊࡜ࡢ౪ᇵ㣴࡛ࡣࡑࢀ࡯࡝ࡢῶᑡࡣ࠶ࡾࡲࡏࢇࠋ

ᅗ㸰ࢢࣛࣇ࡟ࡼࡗ࡚ࡶࡣࡗࡁࡾࢃ࠿ࡾࡲࡍࠋ

(3)

ᅗ㸯                  ᅗ㸰

In vivo ࡢᐇ㦂࡟࠾࠸࡚ࡶࠊCD8+CD122-

⣽ ⬊ ࡢ ࡳ ࢆ ㍺ ὀ ࡉ ࢀ ࡓ ࣜ ࣥ ࣃ ⌫ Ḟ ᦆ ࣐ ࢘ ࢫ㸦RAG-2-/-㸧ࡀ࡝ࢇ࡝ࢇṚࢇ࡛࠸ࡃࡢ࡟ ẚ ࡭ ࠊCD8+CD122+CD49dlow⣽ ⬊ ࢆ ຍ ࠼

࡚ ㍺ ὀ ࡉ ࢀࡓ ࣐ ࢘ ࢫ ࡣ㛗 ࡃ ⏕ Ꮡ ࡋࡲ ࡋ ࡓ ࠋ ࡇࢀࡽࡢᐇ㦂⤖ᯝ࡟ຍ࠼ࠊMHCࢡࣛࢫ Ϩ ࢆ Ḟ ᦆ ࡋ ࡓE2-microglobulin ࣀ ࢵ ࢡ ࢔

࢘ ࢺ ࣐ ࢘ ࢫ ⏤ ᮶ ࡢ ⣽ ⬊ ࢆ ౑ ࡗ ࡓ ᐇ 㦂 ࠊ ࡉ

ࡽ࡟ࡣ FasFasLࡢኚ␗࣐࢘ࢫ࡛࠶ࡿlpr ࣐࢘ࢫࡸgld࣐࢘ࢫࢆ౑ࡗࡓᐇ㦂ࠊ࠶ࡿ࠸ࡣࡑࢀࡽ ࡢኚ␗࣐࢘ࢫ࠿ࡽ᥇ྲྀࡋࡓT⣽⬊ࢆ⏝࠸ࡓᐇ㦂࡞࡝࠿ࡽࠊCD8+CD122+CD49dlow⣽⬊ࡀ⏕యෆ࡟

࠾ࡅࡿච␿⣔ࡢᜏᖖᛶ⥔ᣢࡢࡓࡵ࡟ാࡃ㔜せ࡞ไᚚᛶT⣽⬊࡛࠶ࡿࡇ࡜ࡀ☜ㄆࡉࢀࠊྠไᚚᛶT

⣽⬊ࡣࡑࡢไᚚࡢ㐣⛬࡟࠾࠸࡚MHC ࢡࣛࢫϨ࡜TCRࡢ⤖ྜࢆ௓ࡋ࡚άᛶ໬ T⣽⬊ࢆㄆ㆑ࡋࠊ

Fas/FasL ⤒㊰ࢆ⏝࠸࡚ࡑࢀࡽࡢ⣽⬊ࢆയᐖࡍࡿࡇ࡜࡟ࡼࡾࠊච␿ᢚไస⏝ࢆⓎ᥹ࡋ࡚࠸ࡿࡇ࡜

ࡀศ࠿ࡾࡲࡋࡓࠋ

࠙௒ᚋࡢᒎ㛤ࠚ

◊✲ࢢ࣮ࣝࣉࡀྠᐃࡋࡓ࣓࣮ࣔࣜ⣽⬊ᵝ CD8

ไᚚᛶ T ⣽⬊㸦CD8+CD122+CD49dlow⣽⬊㸧 ࡣࡑࡢ⣽⬊⾲㠃࣐࣮࣮࢝ࠊᶵ⬟ศᏊ࡜ࡶ࡟ච␿グ᠈ࡢ୰ᚰⓗᏑᅾ࡛࠶ࡿ࣓࣮ࣔࣜT ⣽⬊࡜኱ኚ

ࡼࡃఝ㏻ࡗ࡚࠸ࡲࡍࠋ௒ᚋࡣࠊไᚚᛶT⣽⬊࡜࣓࣮ࣔࣜT⣽⬊ࡢ␗ྠࢆᛕ㢌࡟⨨࠸ࡓ◊✲ࡀᚲ せ࡜࡞ࡾࡲࡍࠋFas/FasL⤒㊰ࡣྂࡃ࠿ࡽ▱ࡽࢀ࡚࠸ࡿ࢔࣏ࢺ࣮ࢩࢫ⤒㊰࡛࠶ࡾࠊච␿ไᚚ࡟῝

ᅗ㸱

(4)

ࡃ࠿࠿ࢃࡗ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚࠸ࡲࡍࡀࠊ⏕యෆ࡛࡝ࡢࢱ࢖࣑ࣥࢢ࡛ࠊ࡝ࡢ⣽⬊㞟ᅋ ࡀFas/FasL⤒㊰ࢆ⏝࠸࡚ാ࠸࡚࠸ࡿ࠿ࡣ୙࡛᫂ࡋࡓࠋ௒ᅇࡢ◊✲࡟ࡼࡗ࡚CD8+ไᚚᛶT⣽⬊ ࡢไᚚస⏝࡟ാࡃࡇ࡜ࡀࢃ࠿ࡾࡲࡋࡓࡀࠊࡑࡢ௚ࡢච␿ᢚไ࡟ാࡃศᏊ㸦PD-1 ࡞࡝㸧࡜ࡢ㛵 㐃ࡶྵࡵ࡚௒ᚋࡣ᫂ࡽ࠿࡟ࡋ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡲࡍࠋ

ࡉ ࡽ࡟ ࠊ ◊ ✲ࢢ ࣝ ࣮ ࣉ࡛ 㛤 Ⓨ ࡋࡓ 㑇 ఏ Ꮚ⤌ ᥮ ࠼ ࣐࢘ ࢫ ࡢ ゎᯒ ࡟ ࡼ ࡾࠊ ࡇ ࡢ CD8+CD122+CD49dlowT ⣽⬊ࡀ⭠⅖ࠊ㈋⾑ࠊ㢛⢏⌫ࡢ␗ᖖቑṪ࡞࡝ከࡃࡢච␿␗ᖖ࡟῝ࡃ࠿࠿

ࢃࡗ࡚࠸ࡿࡇ࡜ࡀ♧ࡉࢀࡲࡋࡓࠋࡇࢀࡽࡢ࣐࢘ࢫࢆ⏝࠸ࡓゎᯒࡢᒎ㛤ࡣࠊ≉࡟ᝈ⪅ᩘࡢከ࠸₽

⒆ᛶ኱⭠⅖ࡸࢡ࣮ࣟࣥ⑓ࡢ἞⒪ࢱ࣮ࢤࢵࢺࢆ᥈⣴ࡍࡿୖ࡛ᴟࡵ࡚᭷ᮃ࡛࠶ࡾࠊ௒ᚋ᪂ࡓ࡞⭠⅖

ࣔࢹࣝື≀ࠊཬࡧ἞⒪ἲࡢ㛤Ⓨ࡟⧅ࡆ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡲࡍࠋ

࠙⏝ㄒㄝ᫂ࠚ ไᚚᛶT⣽⬊

T ⣽⬊ࡢ୍㒊࡟ච␿ᛂ⟅ࢆᢚ࠼ࡿാࡁࢆᣢࡗࡓ⣽⬊ࡀᏑᅾࡍࡿࡇ࡜ࡣࠊ㝶ศ௨๓ࡼࡾゝࢃࢀ࡚

࠸ࡲࡋࡓࠋึࡵ࡚ࡑࡢࡼ࠺࡞⣽⬊ࡀᏑᅾࡍࡿ࡜බ⾲ࡉࢀࡓࡢࡣࠊ1971 ᖺ࡟㛤࠿ࢀࡓ➨㸯ᅇࡢ ᅜ㝿ච␿Ꮫ఍࡛ࡢ༓ⴥ኱Ꮫ㸦ᙜ᫬㸧ࡢከ⏣ᐩ㞝༤ኈࡢⓎ⾲࡜ࡉࢀࡲࡍࠋࡑࡢᚋከ⏣༤ኈࡽࡢᥦ ၐࡋࡓᢚไᛶ㸦ࢧࣉࣞࢵࢧ࣮㸧T⣽⬊ࡣࠊ㛵㐃ࡍࡿI-J㑇ఏᏊࡢ▩┪࡞࡝ࡢ⌮⏤࠿ࡽ⾲⯙ྎ࠿ࡽ 㝆ࡾࡲࡍࡀࠊᢚไຊࢆᣢࡘT⣽⬊ࢆࠕไᚚᛶT⣽⬊ࠖ࡜ྡࢆኚ࠼࡚⾲⯙ྎ࡟❧ࡓࡏࡓࡢࡀி㒔

኱Ꮫ㸦ᙜ᫬㸧ࡢᆏཱྀᚿᩥ༤ኈ࡛ࡋࡓࠋᆏཱྀ༤ኈࡣࠊไᚚᛶ T ⣽⬊ࢆ CD4+⣽⬊ࡢࡳ࡟㝈ᐃࡋࠊ ࡑࡢ୰ࡢCD25+⣽⬊࡟⤠ࡾ㎸ࡴࡇ࡜࡛ไᚚᛶT⣽⬊ࢆ☜ᐇ࡟࡜ࡽ࠼ࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋ௨ ᚋࠊCD4+CD25+ไᚚᛶ T ⣽⬊࡟㛵ࡍࡿ◊✲ࡣ㣕㌍ⓗ࡟㐍ࡳࠊྠไᚚᛶ T ⣽⬊࡟ᴟࡵ࡚≉␗ⓗ

࡛࠶ࡿࡢࡳ࡞ࡽࡎไᚚᛶT⣽⬊࡟࡞ࡿࡇ࡜ࢆつᐃࡋ࡚ࡋࡲ࠺Foxp3ࡢⓎぢ࡜┦ࡲࡗ࡚ࠊච␿Ꮫ

◊✲ࡢ୰ࡢ୍኱㡿ᇦࢆᙧᡂࡍࡿ࡟⮳ࡾࡲࡋࡓࠋ

࠙Ⓨ⾲㞧ㄅࠚ

Akane K, Kojima S, Mak TW, Shiku H, Suzuki H. CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity. Proceedings of the National Academy of Science, the United States of America. 2016; (⡿ᅜ᫬

2016211web∧ᥖ㍕㸧

English ver.

http://www.med.nagoya-u.ac.jp/english01/dbps_data/_material_/nu_medical_en/_res/ResearchTopics/2015/CD8_20160211en.pdf



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